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  • Title: [Effect of nonachlazine on the processes of uptake and release of nordrenaline].
    Author: Kaverina NV, Arefolov VA, Grigor'eva EK, Panasiuk LV.
    Journal: Farmakol Toksikol; 1976; 39(4):420-5. PubMed ID: 17545.
    Abstract:
    Nonachlazine (2 micrometer) blocked significantly the uptake 1 of endogenic noradrenaline in the myocardial tissues and in adrenergic neurons of vas deferens. The uptake II, as well as the intensity and dynamics of the noradrenaline release were not affected by nonachlazine. These processes resulted in an increase of free noradrenaline concentrations in the synaptic space. The latter seems to be a result of the mediator's passage into the nerve fibers (through axonal membranes) and into the granule, this being due to the nonachlazine-induced block. It is suggested that the metabolic and functional nonachlazine effects are related to the beta-adrenergic receptors stimulation, mediated through the agency of noradrenaline.
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