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  • Title: Effect of partial replacement of different defatted oil seed cakes as substrate in biosynthesis of bacitracin in solid-state fermentation by Bacillus licheniformis.
    Author: Farzana K, Shah SN, Butt FB, Khan JA.
    Journal: Pak J Pharm Sci; 2007 Jul; 20(3):227-30. PubMed ID: 17545108.
    Abstract:
    The present study was conducted to ascertain the effect of partial replacement of different defatted oil seed cakes as substrate i.e. sunflower meal, rice hulls and soybean meal, in biosynthesis of Bacitracin in Solid-State Fermentation by Bacillus licheniformis on laboratory scale. In solid-state fermentation, wheat bran, soybean meal, sunflower meal, rice hulls and their different combinations were used. The antibiotic activity was determined at various intervals and recorded 48 hours gave maximum yield, 4375 i.u/gm when only soybean was used. However, maximum titre 4820 i.u / gm of antibiotic were obtained when wheat bran and soybean meal was in ratio of 1:3. The raw material for its production is readily available and cheap such as soybean meal, sunflower meal and wheat bran. Thus development of this technology in our country would result in utilizing our own resources in Pakistan.
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