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  • Title: The toll-like receptor 4 Asp299Gly variant and tuberculosis susceptibility in HIV-infected patients in Tanzania.
    Author: Ferwerda B, Kibiki GS, Netea MG, Dolmans WM, van der Ven AJ.
    Journal: AIDS; 2007 Jun 19; 21(10):1375-7. PubMed ID: 17545720.
    Abstract:
    Toll-like receptor 4 (TLR4) plays an important role in the pattern recognition of Mycobacterium tuberculosis, and polymorphisms in the TLR4 gene influence the function of the receptor. We therefore investigated in a cohort of HIV-infected Tanzanian patients whether the Asp299Gly TLR4 polymorphism is associated with the development of active tuberculosis. We found a greater risk of developing active tuberculosis as well as a reduction in CD4 T-cell counts in patients with the Asp299Gly TLR4 polymorphism.
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