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  • Title: Hypermethylation of the p15INK4B gene promoter in B-chronic lymphocytic leukemia.
    Author: Papageorgiou SG, Lambropoulos S, Pappa V, Economopoulou C, Kontsioti F, Papageorgiou E, Tsirigotis P, Dervenoulas J, Economopoulos T.
    Journal: Am J Hematol; 2007 Sep; 82(9):824-5. PubMed ID: 17546638.
    Abstract:
    The p15 gene is a putative tumor suppressor gene that encodes a member of the cyclin dependent kinase inhibitors. Inactivation of p15 by promoter hypermethylation has been postulated as a possible way by which tumor suppressor genes are inactivated in cancer. In this study, we examined the methylation status of the p15 gene promoter in 34 patients with B-Chronic Lymphocytic Leukemia (B-CLL), by the Methylation-Specific Polymerase Chain Reaction. Selective methylation of the p15 gene promoter was found in 4/34 cases (11.8%). According to Rai staging, the four patients with methylated p15 were staged on diagnosis as: 1 on Stage 0, 1 in Stage I, 1 in Stage III, and 1 in Stage IV. Our results suggest that methylation of the p15 gene promoter can be detected in a small subset of B-CLL patients, at all stages of the disease.
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