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  • Title: Leishmania MAP kinases--familiar proteins in an unusual context.
    Author: Wiese M.
    Journal: Int J Parasitol; 2007 Aug; 37(10):1053-62. PubMed ID: 17548090.
    Abstract:
    Mitogen-activated protein kinases are well-known mediators of signal transduction of higher eukaryotes regulating important processes like proliferation, differentiation, stress response and apoptosis. In Leishmania, the typical three-tiered module of MAP kinase signal transduction pathways is present. However, typical activators like cell surface receptors and substrates such as RNA polymerase II transcription factors are missing. Here, I describe the set of 15 putative mitogen-activated protein kinases encoded in the Leishmania genome and discuss their potential function.
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