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  • Title: [Changes in the configuration of synapses in the cerebral cortex in laboratory rats after termination of epileptic seizures during kindling].
    Author: Langmeier M, Hovorka J, Mares J, Trojan S.
    Journal: Sb Lek; 1991 Aug; 93(7-8):197-202. PubMed ID: 1754825.
    Abstract:
    The sensorimotor area of the cerebral cortex of the laboratory rat was repeatedly stimulated by electric current after 10-minute intervals which led to the development a gradual prolongation of self-sustained after-discharges (SSAD). One and 10 minutes after termination of the third SSAD the authors analyzed under the electron microscope synapses type I after to Gray from the second cortical homotopic area of the unstimulated hemisphere. They evaluated the curvature of the active zone of synapses. Evidence was provided that one minute after termination of the fit the number of negatively curved synapses increased and the number of synapses with a straight active zone decreased. The number of synapses with a positively curved active zone does not change. Ten minutes after termination of SSAD in the experimental animals the number of positively curved elements declines and the number of negatively curved synapses increases. There is no significant difference in the number of synapses with a straight active zone. The authors discuss possible functional consequences of the mentioned changes.
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