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Pubmed for Handhelds

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  • Title: Retrospective study of children with hypophosphatasia with reference to dental changes.
    Author: Lundgren T, Westphal O, Bolme P, Modéer T, Norén JG.
    Journal: Scand J Dent Res; 1991 Oct; 99(5):357-64. PubMed ID: 1754836.
    Abstract:
    In the present retrospective study different dental and medical parameters have been analyzed in 17 Swedish children with established hypophosphatasia (HP). It was demonstrated that the basis for the establishment of the diagnosis varied among different dentists and physicians, and that the diagnostic parameters studied among the children varied. The most reliable parameters for HP included raised levels of phosphoethanolamine in urine, and clinical and radiologic findings associated with the legs. These findings were found among the children more often than lowered values of alkaline phosphatase in serum. Histologic analysis of an extracted tooth made a valuable diagnostic complement. It is concluded that a better diagnostic uniformity is recommended. In a well functioning collaboration with well defined tasks, both dentists and physicians can contribute to a reliable diagnosis.
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