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  • Title: Proteome analysis of the rat hepatic stellate cells under high concentrations of glucose.
    Author: Kim PK, Kim MR, Kim HJ, Yoo HS, Kim JS, Cho EH, Kim CW.
    Journal: Proteomics; 2007 Jun; 7(13):2184-8. PubMed ID: 17549797.
    Abstract:
    To study the change in hepatic stellate cell (HSC) function under diabetic conditions, we cultured rat HSC in the presence of 5 and 30 mM glucose, which correspond to blood glucose concentrations during the early and late stages of diabetes, respectively. The differentially expressed HSC proteins were analyzed using 2-DE and ESI-Q-TOF MS/MS and confirmed with Western blotting. The changed protein expression will provide greater understanding of glycolysis in HSC at the high concentration of glucose.
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