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  • Title: Screening for Addison's disease in patients with type 1 diabetes mellitus and recurrent hypoglycaemia.
    Author: Likhari T, Magzoub S, Griffiths MJ, Buch HN, Gama R.
    Journal: Postgrad Med J; 2007 Jun; 83(980):420-1. PubMed ID: 17551075.
    Abstract:
    BACKGROUND: Addison's disease may present with recurrent hypoglycaemia in subjects with type 1 diabetes mellitus. There are no data, however, on the prevalence of Addison's disease presenting with recurrent hypoglycaemia in patients with diabetes mellitus. METHODS: Three year retrospective study of diabetic patients with "unexplained" recurrent hypoglycaemia investigated with a short Synacthen test to exclude adrenocortical insufficiency. RESULTS: 95 patients with type 1 diabetes mellitus were studied. Addison's disease was identified as the cause of recurrent hypoglycaemia in one patient with type 1 diabetes mellitus. CONCLUSION: Addison's disease is a relatively rare but remedial cause of recurrent hypoglycaemia in patients with type 1 diabetes mellitus. A low threshold for investigating patients with type 1 diabetes mellitus and recurrent hypoglycaemia to detect Addison's disease is therefore suggested.
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