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  • Title: Synthesis and characterization of a new red-emitting Ca2+ indicator, calcium ruby.
    Author: Gaillard S, Yakovlev A, Luccardini C, Oheim M, Feltz A, Mallet JM.
    Journal: Org Lett; 2007 Jul 05; 9(14):2629-32. PubMed ID: 17552530.
    Abstract:
    Calcium Ruby m-Cl (X = H, Y = Cl) is a visible-light excited red-emitting calcium concentration ([Ca2+]) indicator dye (579/598 nm peak excitation/emission) with a side arm for conjugation via EDC or click chemistry. Its large molar extinction and high quantum yield rank it among the brightest long-wavelength Ca2+ indicators. Calcium Ruby is a promising alternative to existing dyes for imaging [Ca2+] in multicolor fluorescence applications or in the presence of yellow-green cellular autofluorescence.
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