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  • Title: Imaging pancreatic cancer using surface-functionalized quantum dots.
    Author: Qian J, Yong KT, Roy I, Ohulchanskyy TY, Bergey EJ, Lee HH, Tramposch KM, He S, Maitra A, Prasad PN.
    Journal: J Phys Chem B; 2007 Jun 28; 111(25):6969-72. PubMed ID: 17552555.
    Abstract:
    In this study, CdSe/CdS/ZnS quantum dots (QDs) were used as optical contrast agent for imaging pancreatic cancer cells in vitro using transferrin and anti-Claudin-4 as targeting ligands. CdSe/CdS/ZnS was chosen because the CdSe/CdS/ZnS QDs have better photoluminescence (PL) efficiency and stability than those of CdSe/ZnS. The transferrin-mediated targeting is demonstrated in both a cell-free coprecipitation assay as well as using in vitro confocal microscopy. Pancreatic cancer specific uptake is also demonstrated using the monoclonal antibody anti-Claudin-4. This targeted QD platform will be further modified for the purpose of developing as an early detection imaging tool for pancreatic cancer.
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