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  • Title: Characterization of tableting using the OSDRC system.
    Author: Shimizu K, Ando M, Nakayama Y.
    Journal: Pharm Res; 2007 Oct; 24(10):1902-9. PubMed ID: 17554609.
    Abstract:
    PURPOSE: We compared the compression properties and characteristics of tablets obtained using the OSDRC system (method (OSDRC)) and conventional compression methods including multi-layer compression with a pharmaceutical powder. MATERIALS AND METHODS: We prepared tablets using four methods of compression. The force profiles, ejection force, stress relaxation, pressure transmission ratio, and internal intensity of the tablets were measured as compression properties. RESULTS: Method (OSDRC) gave the highest value for the crushing strength of the tablets. Although the compression properties were similar regardless of the method of compression, the internal intensity of tablets compressed by method (OSDRC) was significantly larger than that of the tablets produced by the other methods. CONCLUSIONS: In terms of crushing strength, the tablets compressed by method (OSDRC) were superior of those obtained by the conventional compression method. Therefore, it is possible to increase the crushing strength of tablets without changing the pharmaceutical formulation.
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