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  • Title: Vaccination of newborns against hepatitis A in the presence of maternally derived antibodies.
    Author: Vidor E.
    Journal: J Comp Pathol; 2007 Jul; 137 Suppl 1():S42-5. PubMed ID: 17555761.
    Abstract:
    Infection by hepatitis A virus (HAV) is a significant cause of childhood disease but effective vaccines are available. Naturally acquired anti-HAV antibodies ensure transfer of protective immunity which persists for up to 6 months in the newborn. Such maternal anti-HAV antibodies are able to inhibit the antibody responses in infants vaccinated with inactivated hepatitis A vaccines, although no clinically significant consequences of this are observed. By increasing the number of doses, for example by using a three dose primary vaccination schedule, and by increasing the amount of vaccinal antigen, this interfering effect may be partially overcome.
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