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  • Title: cAMP induced alterations of Chinese hamster ovary cells monitored by mass spectrometry.
    Author: Spera R, Nicolini C.
    Journal: J Cell Biochem; 2007 Oct 01; 102(2):473-82. PubMed ID: 17557277.
    Abstract:
    Chinese Hamster Ovary fibroblasts (CHO-K1) have shown different protein contents when undergoing differentiation by 3',5'-cyclic adenosine monophosphate (cAMP), which is known to induce reverse transformation (RT) from malignancy to fibroblast-like characteristics. The mass spectrometry (MS) investigation here reported about the behavior of CHO-K1 cells before and after exposure to cAMP reveals a change in the composition of nuclear proteins associated to an inhibition of the protein expression. Possible implications of this finding on the control of cell reverse transformation are discussed.
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