These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Perchlorate inhibition of iodide uptake in normal and iodine-deficient rats.
    Author: Paulus BF, Bazar MA, Salice CJ, Mattie DR, Major MA.
    Journal: J Toxicol Environ Health A; 2007 Jul; 70(13):1142-9. PubMed ID: 17558809.
    Abstract:
    Perchlorate-induced inhibition of thyroidal iodide uptake was measured in normal and iodine-deficient female Sprague-Dawley rats. Rats that were made iodine-deficient by long-term restriction of iodine in the diet absorbed a gavage dose of 131I to the thyroid in proportionally greater amounts than rats fed a normal diet. Furthermore, the iodine-deficient rats maintained their high rates of absorption even when challenged by levels of perchlorate in their drinking water sufficient to produce pronounced inhibition of 131I uptake in rats fed a normal diet. Every dose of perchlorate used in this study (1.1, 5.6, and 28 mg/L) produced significant inhibition of iodide uptake in normally fed rats, but only the highest level of perchlorate (28 mg/L) significantly inhibited thyroidal uptake of 131I in the iodine-deficient rats. Taken together, these results demonstrate that iodide-deficient animals exhibit increased resistance to the inhibition of iodine absorption resulting from perchlorate exposure.
    [Abstract] [Full Text] [Related] [New Search]