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  • Title: HLA typing in Vogt-Koyanagi-Harada syndrome in North Indian patients.
    Author: Gupta A, Kamal S, Gupta V, Bambery P, Kaura B.
    Journal: Ocul Immunol Inflamm; 2007; 15(2):89-97. PubMed ID: 17558833.
    Abstract:
    PURPOSE: To report the HLA profile of VKH patients from India. METHOD: Forty-one patients and 50 controls were studied. Phenotyping using a lymphocytotoxicity assay was done for HLA-A and -B. DNA-based sequence-specific low resolution typing was done for HLA-DR and -DQ loci. RESULTS: HLA-A9 was over-represented in the patient population (p = 0.01), whereas HLA-A11 (p = 0.03) and HLA-DRB1*13 (p = 0.007) were found to be underrepresented. The frequency of HLA-DRB1*04 was 14.6% and 10% in the patient population and controls, respectively. The HLA-DQ frequencies did not differ significantly between patients and controls. CONCLUSION: Unlike that reported in most populations, we did not find a significant association between HLA-DRB1*04 and our patient population.
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