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  • Title: HLA-G alleles and HLA-G 14 bp polymorphisms in a Brazilian population.
    Author: Castelli EC, Mendes-Junior CT, Donadi EA.
    Journal: Tissue Antigens; 2007 Jul; 70(1):62-8. PubMed ID: 17559583.
    Abstract:
    Brazilians represent one of the most heterogeneous populations in the world as the result of five centuries of interethnic crosses. We investigated the polymorphism of the HLA-G locus in a Brazilian urban sample. HLA-G alleles were determined by SBT analysis of exons 2-4 and 8 in 103 unrelated individuals. The genotyping analysis identified 11 different HLA-G alleles, including the recently described G*010110 allele, and four new variants in this population. These data indicate that this Brazilian population presents high HLA-G allelic polymorphism, suggesting increased levels of intrapopulational genetic diversity that may be because of the admixed nature of the sample. This is the first study regarding HLA-G genotyping that was performed at such refined resolution level in this heterogeneous population.
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