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  • Title: Prevalence and correlates of comorbidity 8 years after a first psychotic episode.
    Author: Farrelly S, Harris MG, Henry LP, Purcell R, Prosser A, Schwartz O, Jackson H, McGorry PD.
    Journal: Acta Psychiatr Scand; 2007 Jul; 116(1):62-70. PubMed ID: 17559602.
    Abstract:
    OBJECTIVE: While rates and correlates of comorbidity have been investigated in the early course of psychosis, little is known about comorbidity in the medium-to-longer term or its relationship with outcome. METHOD: A total of 182 first-episode psychosis (FEP) patients who met DSM-IV criteria for a current psychotic disorder 8 years after index presentation were grouped according to concurrent comorbidity [no concurrent axis I disorder; concurrent substance use disorder (SUD); other concurrent axis I disorder; concurrent SUD and other axis I disorder]. Outcomes were compared between groups controlling for relevant covariates. RESULTS: As much as 39% met criteria for one or more concurrent axis 1 diagnoses. Comorbidity was associated with greater severity of general psychopathology, but not with measures of functioning, treatment or negative symptoms. CONCLUSION: Specific combinations of comorbid disorders may influence patterns of psychotic symptomatology. Routine examination of axis I disorders is warranted in the ongoing management of psychosis.
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