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  • Title: The effects of subcutaneous deferoxamine administration on renal function in thalassemia major.
    Author: Koren G, Kochavi-Atiya Y, Bentur Y, Olivieri NF.
    Journal: Int J Hematol; 1991 Oct; 54(5):371-5. PubMed ID: 1756248.
    Abstract:
    To assess the effects of deferoxamine (DFO) on the kidneys, we studied 27 patients with thalassemia major on chronic subcutaneous (s.c.) DFO therapy. In 41% of the patients glomerular filtration rate (GFR) values were above the normal range. In a previous study similar findings were reported for thalassemia patients who did not receive DFO. The subcutaneous administration of DFO was associated with a clinically significant decrease in GFR in 40% of the patients and in a mild decrease in another 40%. In all cases of severe decreases in GFR, it tended to return to baseline values upon discontinuation of DFO. There was a significant increase in urine volume during DFO therapy. These changes are consistent with our previous observation in humans and dogs receiving high dose i.v. DFO, albeit milder.
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