These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Apnea in a child after oral codeine: a genetic variant - an ultra-rapid metabolizer.
    Author: Voronov P, Przybylo HJ, Jagannathan N.
    Journal: Paediatr Anaesth; 2007 Jul; 17(7):684-7. PubMed ID: 17564651.
    Abstract:
    We present a case of a 29 months old previously healthy child who experienced apnea resulting in brain injury following a dose of acetaminophen and codeine 2 days after an uneventful anesthetic for tonsillectomy. A genetic polymorphism leading to ultra-rapid metabolism of codeine into morphine resulted in narcosis and apnea. This paper discusses the use of codeine for pain relief, obstructive sleep apnea, the alteration of the CYP2D6 gene and the resulting effect on drug metabolism.
    [Abstract] [Full Text] [Related] [New Search]