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  • Title: Translocation (8;21) in acute nonlymphocytic leukemia delineated by chromosomal in situ suppression hybridization.
    Author: Popp S, Jauch A, Qiu JY, Smialek B, Cremer T, Becher R.
    Journal: Cancer Genet Cytogenet; 1991 Nov; 57(1):103-7. PubMed ID: 1756476.
    Abstract:
    In situ suppression hybridization with recombinant bacteriophage DNA libraries for chromosomes 8 and 21 was performed in two cases of acute nonlymphocytic leukemia, type FAB M2. In both cases, cytogenetic analysis by conventional G-banding revealed t(8;21)(q22;q22). In situ suppression hybridization was able to prove the reciprocal nature of the translocation in both cases by identifying the terminal end of chromosome 21 translocated to the derivative chromosome 8q-.
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