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  • Title: Cytotoxic clerodane diterpenoids from fruits of Casearia grewiifolia.
    Author: Kanokmedhakul S, Kanokmedhakul K, Buayairaksa M.
    Journal: J Nat Prod; 2007 Jul; 70(7):1122-6. PubMed ID: 17567069.
    Abstract:
    Bioactivity-guided fractionation of the ethyl acetate-soluble fraction of a methanol extract of the fruits of Casearia grewiifolia afforded eight new clerodane diterpenes, caseargrewiins E-L (1-8), and a known clerodane diterpene, esculentin B (9). The structures of 1-8 were established on the basis of 1D and 2D NMR spectroscopic data. Most of these compounds exhibited cytotoxicity against three cancer cell lines with IC50 values in the range 0.15-6.00 microg/mL.
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