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  • Title: Ratio of serum ornithine carbamoyltransferase to alanine aminotransferase as a potent indicator for hepatocellular carcinoma.
    Author: Murayama H, Fukuda Y, Tsunekawa S, Ikemoto M, Nagata A.
    Journal: Clin Biochem; 2007 Sep; 40(13-14):1077-80. PubMed ID: 17570354.
    Abstract:
    OBJECTIVES: To evaluate the clinical advantage of the ratio of serum ornithine carbamoyltransferase (OCT) to alanine aminotransferase (ALT) in the diagnosis of hepatocellular carcinoma (HCC). DESIGN AND METHODS: Serum levels of hepatic enzyme markers and their combinations were evaluated and compared with those of two other markers for HCC. RESULTS: OCT/ALT was significantly higher in case of HCC than chronic hepatitis or liver cirrhosis. Its sensitivity (64.3%) was higher than those of alpha-fetoprotein and PIVKA-II (21.4% and 42.9%, respectively). Fluctuations of OCT/ALT before and after treatment were similar to those of alpha-fetoprotein. CONCLUSIONS: OCT/ALT is a potent indicator for the diagnosis and the prognosis of HCC.
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