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  • Title: Antifungal dibenzofuran bis(bibenzyl)s from the liverwort Asterella angusta.
    Author: Qu J, Xie C, Guo H, Yu W, Lou H.
    Journal: Phytochemistry; 2007 Jul; 68(13):1767-74. PubMed ID: 17570447.
    Abstract:
    Bioactivity-guided separation of an antifungal extract from the liverwort Asterella angusta afforded four bis(bibenzyl)s, asterelin A (1), asterelin B (2), 11-O-demethyl marchantin I (3), and dihydroptychantol A (4), together with six known ones. Their structures were established by extensive spectroscopic analysis (1D and 2D-NMR, MS), and that of 2 was confirmed by X-ray crystallographic diffraction analysis. Compounds 1 and 2 are the first examples of dibenzofuran bis(bibenzyl)s. The antifungal activity of the isolated bis(bibenzyl)s against the common clinical pathogenic fungus Candida albicans was evaluated using both the thin-layer chromatography bioautographic assay and the broth microdilution method. They showed moderate antifungal activities with minimal inhibitory concentration (MIC) values ranging from 16 microg/ml to 512 microg/ml.
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