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  • Title: [Visually evoked cortical potentials for early detection of optic neuritis in ethambutol therapy].
    Author: Dette TM, Spitznas M, Göbbels M, Koch F, Leinhos C.
    Journal: Fortschr Ophthalmol; 1991; 88(5):546-8. PubMed ID: 1757046.
    Abstract:
    Ethambutol leads to chronic, severe optic neuritis with sudden onset in approximately 5-14% of all patients. Therefore, the ability of visually (pattern) evoked potentials for the early diagnosis of ethambutol-induced optic neuritis was tested. During ethambutol therapy prolonged latency was documented in 5 of 15 cases (33%). One of these 5 cases showed a reversible decrease in visual acuity. Thus, during treatment with ethambutol visually (pattern) evoked potentials may reveal a surprisingly high percentage of subclinical optic neuritis. These patients need close supervision in order to facilitate early discontinuation of the drug when neuritis develops.
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