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Title: Synthesis of benzothiazole semicarbazones as novel anticonvulsants--the role of hydrophobic domain. Author: Siddiqui N, Rana A, Khan SA, Bhat MA, Haque SE. Journal: Bioorg Med Chem Lett; 2007 Aug 01; 17(15):4178-82. PubMed ID: 17572089. Abstract: A series of 1,3-benzothiazol-2-yl semicarbazones (1-15) were prepared in satisfactory yield and evaluated for their anticonvulsant, neurotoxicity and other toxicity studies. All the synthesized compounds were in good agreement with elemental and spectral data. Majority of the compounds were active in MES screen. Selected compounds were checked for their lipophilic character.[Abstract] [Full Text] [Related] [New Search]