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  • Title: Halothane action on lymphocytes does not involve cyclic AMP.
    Author: Bruce DL.
    Journal: Anesthesiology; 1976 Feb; 44(2):151-4. PubMed ID: 175725.
    Abstract:
    Both theophylline and halothane inhibited transformation of human lymphocytes by phytohemagglutinin (PHA). Theophylline did not augment the inhibitory action of halothane and depressed PHA transformation of halothane-treated cells to the same extent as that of air-treated cells. Halothane- and air-treated lymphocytes, prior to PHA addition, had the same content of cyclic AMP. The addition of PHA to these cultures raised cyclic-AMP concentrations to the same extent in halothane- and air-treated lymphocytes. Halothane action on PHA-stimulated lymphocytes appears not to involve changes in cyclic nucleotide metabolism.
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