These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.
Pubmed for Handhelds
PUBMED FOR HANDHELDS
Search MEDLINE/PubMed
Title: Gaucher disease: different clinical manifestations associated with a rare mutation (R48W) in a Lebanese family. Author: El-Zahabi LM, Makarem J, Habbal Z, Otrock ZK, Taher A, Shamseddine A. Journal: Mol Genet Metab; 2007 Aug; 91(4):402-4. PubMed ID: 17574891. Abstract: Gaucher disease (GD) is the most frequently encountered lysosomal storage disease, caused by autosomal recessive inborn defects in the glucocerebrosidase gene (GBA) at 1q21. The disease is most common in the Ashkenazi Jewish population. GD can present with a vast phenotypic heterogeneity, which can be predicted to some extent from the underlying mutation. In this report, we describe a Lebanese Arab family with multigenerational incidence of GD caused by a heterozygous genotype of a rare mutation, R48W, and a common one, L444P. Our patients' clinical course is described. We also review the English literature for patients with this rare mutation.[Abstract] [Full Text] [Related] [New Search]