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  • Title: Evaluation of a commercial measles virus immunoglobulin M enzyme immunoassay.
    Author: Mayo DR, Brennan T, Cormier DP, Hadler J, Lamb P.
    Journal: J Clin Microbiol; 1991 Dec; 29(12):2865-7. PubMed ID: 1757560.
    Abstract:
    Paired serum samples from 93 patients suspected of having measles were assayed for measles virus-specific immunoglobulin M (IgM) antibodies by an enzyme immunoassay (EIA), and the results were compared with results from a complement fixation assay and an EIA for measles virus IgG. By using significant serologic rises as the standard for comparison, the IgM EIA assay had a sensitivity of 85.7%, a specificity of 81.3%, a positive predictive value of 95.7%, and a negative predictive value of 54.2%. This assay can be expected to perform well in outbreak situations.
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