These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Effects of ethanol on midbrain neurons: role of opioid receptors.
    Author: Xiao C, Zhang J, Krnjević K, Ye JH.
    Journal: Alcohol Clin Exp Res; 2007 Jul; 31(7):1106-13. PubMed ID: 17577392.
    Abstract:
    BACKGROUND: Although ethanol addiction is believed to be mediated by the mesolimbic dopamine system, originating from the ventral tegmental area (VTA), how acute ethanol increases the activity of VTA dopaminergic (DA) neurons remains unclear. METHOD: Patch-clamp recordings of spontaneous firings of DA and GABAergic neurons in the VTA in acute midbrain slices from rats. RESULTS: Ethanol (20-80 mM) excites DA neurons, and more potently depresses firing of local GABAergic neurons. The ethanol-induced excitation of DA neurons is considerably attenuated by DAMGO (Tyr-d-Ala-Gly-N-Me-Phe-Gly-ol enkephalin), a mu-opioid agonist that suppresses firing of GABAergic neurons, or by naloxone, a general opioid antagonist. The ongoing opioid-induced facilitation of DA cell firing (revealed by naloxone) is enhanced by ethanol, probably by an increase in opioid release or action. CONCLUSION: Ethanol excites VTA DA neurons at least partly by increasing ongoing opioid-mediated suppression of local GABAergic inhibition. This indirect mechanism may contribute significantly to the positively reinforcing properties of ethanol.
    [Abstract] [Full Text] [Related] [New Search]