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  • Title: CuI-catalyzed domino process to 2,3-disubstituted benzofurans from 1-bromo-2-iodobenzenes and beta-keto esters.
    Author: Lu B, Wang B, Zhang Y, Ma D.
    Journal: J Org Chem; 2007 Jul 06; 72(14):5337-41. PubMed ID: 17579459.
    Abstract:
    CuI-catalyzed coupling of 1-bromo-2-iodobenzenes with beta-keto esters in THF at 100 degrees C leads to 2,3-disubstituted benzofurans. This domino transformation involves an intermolecular C-C bond formation and a subsequent intramolecular C-O bond formation process. Benzofurans with different substituents at the 5- and 6-position are accessible by employing the corresponding 1-bromo-2-iodobenzenes.
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