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  • Title: Highly polar spiroisoxazolines from the sponge Aplysina fulva.
    Author: Rogers EW, Molinski TF.
    Journal: J Nat Prod; 2007 Jul; 70(7):1191-4. PubMed ID: 17579462.
    Abstract:
    Two new highly polar brominated spiroisoxazolines, araplysillin N9-sulfamate (1) and an N-[5S,10R)-7,9-dibromo-10-hydroxy-8-methoxy-1-oxa-2-azaspiro[4.5]deca-2,6,8-triene-3-carboxy]-4-aminobutanoic acid (2), were isolated from a sample of Aplysina fulva collected in the Florida Keys. The absolute stereostructures of the new compounds were determined from analysis of MS, 1H and 13C NMR, and CD spectroscopy. Compound 2 provides a structural clue that may unify the biosynthesis of brominated spiroisoxazolines.
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