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  • Title: Crystal shedding and acute pseudogout. An hypothesis based on a therapeutic failure.
    Author: Bennett RM, Lehr JR, McCarty DJ.
    Journal: Arthritis Rheum; 1976; 19(1):93-7. PubMed ID: 175804.
    Abstract:
    Four patients with chondrocalcinosis of the knees volunteered for joint lavage. Preliminary experiments indicated that disodium EDTA and magnesium ions were potent solubilizers of CPPD crystals. The procedure was a therapeutic failure in that insignificant amounts of CPPD were removed and all 4 subjects developed postlavage attacks of pseudogout. It is hypothesized that the acute attack of pseudogout is a result of crystal shedding and may be triggered by any factor that enhances CPPD solubility.
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