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  • Title: Signet-ring cell carcinoma presenting in the uterine cervix: report of a primary and 2 metastatic cases.
    Author: Suárez-Peñaranda JM, Abdulkader I, Barón-Duarte FJ, González Patiño E, Novo-Domínguez A, Varela-Durán J.
    Journal: Int J Gynecol Pathol; 2007 Jul; 26(3):254-8. PubMed ID: 17581407.
    Abstract:
    Signet-ring cell carcinoma presenting in the uterine cervix is an uncommon neoplasm. It is usually a metastasis from a primary gastric tumor; only rarely, cervical involvement is the first manifestation of the disease. Primary signet-ring carcinoma of the cervix is extremely unusual, and it is always necessary to rule out a metastatic neoplasm. We report 3 cases of signet-ring cell carcinoma diagnosed in cervical biopsies. All cases were initially considered as metastatic, but a primary site other than the cervix could be confirmed in only 2 cases. Although autopsy was not authorized, a very comprehensive clinical workup and the evolution of the disease support the interpretation of the third case as a primary neoplasm. Primary signet-ring cell carcinoma of the cervix is an extraordinary event-the diagnosis of which requires excluding a metastasis from the gastrointestinal tract (usually the stomach), the ovary, or the breast.
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