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  • Title: Expression and characterization of a minimal hepatitis C virus glycoprotein E2 core domain that retains CD81 binding.
    Author: McCaffrey K, Boo I, Poumbourios P, Drummer HE.
    Journal: J Virol; 2007 Sep; 81(17):9584-90. PubMed ID: 17581991.
    Abstract:
    The hepatitis C virus glycoprotein E2 receptor-binding domain is encompassed by amino acids 384 to 661 (E2(661)) and contains two hypervariable sequences, HVR1 and HVR2. E2 sequence comparisons revealed a third variable region, located between residues 570 and 580, that varies widely between genotypes, designated here as igVR, the intergenotypic variable region. A secreted E2(661) glycoprotein with simultaneous deletions of the three variable sequences retained its ability to bind CD81 and conformation-dependent monoclonal antibodies (MAbs) and displayed enhanced binding to a neutralizing MAb directed to E2 immunogenic domain B. Our data provide insights into the E2 structure by suggesting that the three variable regions reside outside a conserved E2 core.
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