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  • Title: Commitment and developmental potential of extrathymic and intrathymic T cell precursors: plenty to choose from.
    Author: Bhandoola A, von Boehmer H, Petrie HT, Zúñiga-Pflücker JC.
    Journal: Immunity; 2007 Jun; 26(6):678-89. PubMed ID: 17582341.
    Abstract:
    T cells developing in the thymus are derived from hematopoietic stem cells (HSCs) in the bone marrow (BM). Understanding the developmental steps linking multipotent HSCs to intrathymic T lineage-committed progenitors is important for understanding cancer in T lineage cells, improving T cell reconstitution after BM transplantation, and designing gene-therapy approaches to treat defective T cell development or function. Such an understanding may also help ameliorate immunological defects in aging. This review covers the differentiation steps between HSCs and committed T cell progenitors within the thymus.
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