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  • Title: Synthesis and cannabinoid activity of 1-substituted-indole-3-oxadiazole derivatives: novel agonists for the CB1 receptor.
    Author: Moloney GP, Angus JA, Robertson AD, Stoermer MJ, Robinson M, Wright CE, McRae K, Christopoulos A.
    Journal: Eur J Med Chem; 2008 Mar; 43(3):513-39. PubMed ID: 17582659.
    Abstract:
    An exploratory chemical effort has been undertaken to develop a novel series of compounds as selective CB(1) agonists. It is hoped that compounds of this type will have clinical utility in pain control, and cerebral ischaemia following stroke or traumatic head injury. We report here medicinal chemistry studies directed towards the investigation of a series of 1-substituted-indole-3-oxadiazoles as potential CB(1) agonists.
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