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  • Title: Analysis of sofalcone in human plasma by high performance liquid chromatography.
    Author: Wen A, Wang Z, Hang T, Jia Y, Zhang T, Wu Y, Gao X, Yang Z.
    Journal: J Chromatogr B Analyt Technol Biomed Life Sci; 2007 Sep 01; 856(1-2):348-52. PubMed ID: 17586104.
    Abstract:
    A simple, rapid, sensitive and reliable high performance liquid chromatography (HPLC) method for the determination of the anti-ulcer drug sofalcone in human plasma was developed. Plasma was extracted with ethyl acetate under acidic conditions and sofalcone was determined by HPLC using a C18 column and (methanol-0.1% formic acid aqueous 80:20) mobile phase. The linear calibration curves of sofalcone in human plasma were obtained over the concentration range of 0.01-5.0 microg/ml. The lower limit of quantitation (LLOQ) was 10 ng/ml in human plasma. The precision measured for plasma was within 15%. Extraction recovery was over 85% in blood. The method was successfully applied to the identification and quantification of sofalcone in pharmacokinetic studies.
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