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  • Title: Prenatal dysthymia versus major depression effects on maternal cortisol and fetal growth.
    Author: Field T, Diego MA, Hernandez-Reif M, Figueiredo B, Ascencio A, Schanberg S, Kuhn C.
    Journal: Depress Anxiety; 2008; 25(6):E11-6. PubMed ID: 17587221.
    Abstract:
    To determine differences between pregnant women diagnosed with Dysthymia versus Major Depression, depressed pregnant women (N=102) were divided by their diagnosis into Dysthymic (N=48) and Major Depression (N=54) groups and compared on self-report measures (depression, anxiety, anger, daily hassles and behavioral inhibition), on stress hormone levels (cortisol and norepinephrine), and on fetal measurements. The Major Depression group had more self-reported symptoms. However, the Dysthymic group had higher prenatal cortisol levels and lower fetal growth measurements (estimated weight, femur length, abdominal circumference) as measured at their first ultrasound (M=18 weeks gestation). Thus, depressed pregnant women with Dysthymia and Major Depression appeared to have different prenatal symptoms.
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