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  • Title: Hypothalamo-pituitary adrenocortical function in the rat after treatment with betamethasone.
    Author: Buckingham JC, Hodges JR.
    Journal: Br J Pharmacol; 1976 Feb; 56(2):235-9. PubMed ID: 175875.
    Abstract:
    1 Hypothalamo-pituitary-adrenocortical (HPA) activity was suppressed in rats treated with betamethasone. 2 Recovery of normal HPA function occurred after corticosteroid withdrawl. 3 Although corticotrophin release was rapidly restored to its basal rate there was a delay in the return of the normal adrenocorticotrophic response to stress and normal adrenocortical function was evident only after the plasma adrenocorticotrophic hormone had reached 'supra-normal' levels. 4 The physiological significance and possible clinical relevance of the results are discussed.
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