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  • Title: Impact of human metapneumovirus and respiratory syncytial virus co-infection in severe bronchiolitis.
    Author: McNamara PS, Flanagan BF, Smyth RL, Hart CA.
    Journal: Pediatr Pulmonol; 2007 Aug; 42(8):740-3. PubMed ID: 17588245.
    Abstract:
    We have previously shown high rates of co-infection with Respiratory Syncytial Virus (RSV) and human Metapneumovirus (hMPV) in infants with severe bronchiolitis at our institution in 2000-2002, and that co-infection was associated with increased disease severity. In this study, we have attempted to identify differences in intubated infants with severe RSV infection with and without hMPV co-infection. Here we show that RSV+/hMPV+ were clinically symptomatic for longer than RSV+/hMPV- infants, but that no differences in airway total cell concentration, differential cell count or cytokine/chemokine concentrations were detectable.
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