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  • Title: Role of capsaicin-sensitive sensory nerves in protease-activated receptor-2-mediated contraction of rat urinary bladder.
    Author: Shimizu N, Nakahara T, Saito M, Ishii K.
    Journal: Eur J Pharmacol; 2007 Aug 13; 569(1-2):145-8. PubMed ID: 17588562.
    Abstract:
    The capsaicin receptor, transient receptor potential vanilloid receptor 1 (TRPV1), colocalizes with protease-activated receptors (PARs) in the urinary bladder, but functional interaction between TRPV1 and PARs remains to be clarified. In the present study, the role of capsaicin-sensitive sensory neurons in contraction induced by activation of PAR-2 was investigated in the rat urinary bladders. The contractile responses to trypsin and the PAR-2 agonist 2-furoyl-LIGRL-NH(2) were significantly attenuated by either desensitization of sensory neurons achieved by capsaicin (10 microM) or by the TRPV1 antagonist capsazepine (30 microM). These results suggest that stimulation of capsaicin-sensitive sensory fibers contributes, at least in part, to PAR-2-mediated bladder contractions in rats.
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