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  • Title: Necrotizing gingivitis: a possible oral manifestation of ticlopidine-induced agranulocytosis.
    Author: Rajandram RK, Ramli R, Karim F, Rahman RA, Fun LC.
    Journal: N Z Med J; 2007 Jun 15; 120(1256):U2590. PubMed ID: 17589558.
    Abstract:
    Agranulocytosis is a rare complication of ticlopidine and can be life-threatening. We report a case of ticlopidine-induced agranulocytosis and neutropenia (neutrophil count of 0.1 x 10(9)/L) with necrotizing gingivitis in a 54-year-old Malaysian-Chinese female. She was started on ticlopidine 250 mg twice daily 3 weeks prior to this hospital admission. We started her on intravenous metronidazole and amoxicillin and clavulanic acid (Augmentin) and concurrently stopped ticlopidine. A series of clinical and laboratory investigations were carried out and a final diagnosis of necrotizing gingivitis possibly secondary to agranulocytosis was made. The patient was discharged home after 2 weeks of hospitalisation.
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