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  • Title: Increasing ceftriaxone resistance and multiple alterations of penicillin-binding proteins among penicillin-resistant Streptococcus pneumoniae isolates in Taiwan.
    Author: Chiu CH, Su LH, Huang YC, Lai JC, Chen HL, Wu TL, Lin TY.
    Journal: Antimicrob Agents Chemother; 2007 Sep; 51(9):3404-6. PubMed ID: 17591850.
    Abstract:
    The rate of nonsusceptibility of penicillin-resistant Streptococcus pneumoniae strains to ceftriaxone increased significantly in Taiwan in 2005. Approximately 90% of the ceftriaxone-nonsusceptible isolates were found to be of four major serotypes (serotypes 6B, 14, 19F, and 23F). Seven amino acid alterations in the penicillin-binding protein 2B transpeptidase-encoding region specifically contributed to the resistance.
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