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  • Title: [Primary non-Hodgkin's lymphomas of the central nervous system. Still more questions than answers in the treatment?].
    Author: Hansen PB, Jensen MK.
    Journal: Ugeskr Laeger; 2007 Jun 04; 169(23):2187-9. PubMed ID: 17592682.
    Abstract:
    The optimal treatment of primary non-Hodgkin"s lymphomas of the central nervous system is still under discussion. Systemic treatment is compromised by the blood-brain barrier which is impermeable to several cytostatic agents. For several years, the standard treatment has been methotrexate-based chemotherapy followed by CNS-radiotherapy. However, this combination therapy may be complicated by later neurotoxicity. Intensive chemotherapy followed by autologous stem-cell transplantation is a new promising treatment approach without increased CNS-toxicity.
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