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  • Title: Clinical experience in the treatment of normal tension glaucoma with latanoprost in Germany.
    Author: Thelen U, Weiler W, Kirchhoff E, Fuchs HB, Stewart WC.
    Journal: J Ocul Pharmacol Ther; 2007 Jun; 23(3):311-3. PubMed ID: 17593016.
    Abstract:
    AIMS: The aim of this analysis was to evaluate the general ophthalmologist's experience in using latanoprost to treat normal tension glaucoma (NTG) patients. METHODS: NTG patients included in this study were part of an observational cohort of patients that were changed from previous therapy to latanoprost in Germany. RESULTS: This study included 200 NTG glaucoma patients who were being treated with latanoprost monotherapy (average duration, 1.2 +/- 1.4 years) and had 6 months of follow-up. At the beginning of the observation period, patients had an average intraocular pressure (IOP) of 15.2 +/- 2.5 mmHg and after 6 months, 15.0 +/- 2.4 mmHg (P = 0.769). Eight (8) patients (4.0%) were discontinued from latanoprost during the observation period, with the most common reason noted as the need for further IOP reduction (n = 7; 3.5%). Twenty-four (24) patients (12.0%) noted at least one ocular adverse event during the observation period, with the most common reason noted as burning/stinging (n = 9; 4.5%) or conjunctival hyperemia (n = 9; 4.5%). CONCLUSIONS: This study suggests that patients with NTG who are already treated with latanoprost monotherapy should continue to have, over a short-term follow-up, generally stable IOPs, low side-effect incidence, and discontinuations, as well as "very good" to "excellent" physician ratings of patient efficacy, tolerability, and satisfaction.
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