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  • Title: Cardiac troponin I concentrations in people presenting with diabetic ketoacidosis.
    Author: Geddes J, Deans KA, Cormack A, Motherwell D, Paterson K, O'Reilly DS, Fisher BM.
    Journal: Ann Clin Biochem; 2007 Jul; 44(Pt 4):391-3. PubMed ID: 17594788.
    Abstract:
    BACKGROUND: Elevated troponin concentrations may be observed in a wide spectrum of medical disorders in people without evidence of overt ischaemic heart disease. The prospective relationship between serum cardiac troponin I (cTnI) and diabetic ketoacidosis (DKA) has not been examined in adults. METHODS: Forty patients (14 male and 26 female) with type 1 diabetes were recruited. cTnI, creatine kinase (CK), cystatin C and beta-hydroxybutyrate were measured on admission and at 24, 48 and 72 h post-admission. Daily electrocardiographs were also performed. RESULTS: Four out of forty subjects presenting with DKA had an increase in cTnI (median (SD) 0.06 (0.31) microg/L). One of the subjects had multiple possible reasons for the elevated cTnI concentration. However, the other three subjects had no obvious precipitating factors. This cohort underwent echocardiography and thallium-201 scintigraphy, which revealed no abnormalities. CONCLUSIONS: Minor troponin elevations appear to occur in a small number of subjects with type 1 diabetes presenting with DKA. The clinical relevance of this at this stage remains unknown and further large-scale studies are suggested.
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