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  • Title: Effects of Salvia officinalis L. extract on experimental acute inflammation.
    Author: Oniga I, Pârvu AE, Toiu A, Benedec D.
    Journal: Rev Med Chir Soc Med Nat Iasi; 2007; 111(1):290-4. PubMed ID: 17595884.
    Abstract:
    UNLABELLED: The aim of this study was to investigate the effects of Salvia officinalis L. tincture on acute inflammation induced with oil of turpentine. MATERIALS AND METHODS: Oil of turpentine (i.m. 0.6 ml/100 g b.w.) was injected into male Wistar rats right hind paw. Salviae folium tincture and diclofenac as positive control (30 mg/100 g b.w.) were administrated i.p. The effects were evaluated by measuring total leukocyte count and differential leukocyte count expressed as a percentage, a test of in vitro phagocytosis and evaluation of nitric oxide synthesis by measuring the metabolites: nitrites and nitrates. RESULTS: Salvia officinalis tincture significantly reduced the total leukocyte and monocytes percentages and the activation of circulating phagocytes. NO synthesis had a slight decrease. Salvia officinalis tincture had a smaller inhibitory effect than diclofenac. CONCLUSIONS: Salvia officinalis tincture had antiinflammatory effects by reducing marrow acute phase response and NO synthesis.
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