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  • Title: Clopidogrel-induced spontaneous spinal epidural hematoma.
    Author: Sung JH, Hong JT, Son BC, Lee SW.
    Journal: J Korean Med Sci; 2007 Jun; 22(3):577-9. PubMed ID: 17596676.
    Abstract:
    The hemorrhagic side effects associated with the use of clopidogrel are within the acceptable range and occur mainly at skin or gastrointestinal sites. We report a case of spontaneous spinal epidural hematoma (SSEH) in a 60-yr-old woman who was treated with clopidogrel for frequent transient ischemic attacks. To our knowledge, this is the second reported case of clopidogrel-induced SSEH. The patient's symptoms and past history of clopidogrel use suggested the diagnosis and made the procedure proceed quickly to operate SSEH 9 hr after the onset of paraplegia. The outcome was excellent. Therefore, with the popularity of antiplatelet prescription, physicians should keep in mind and urgently treat this unusual but critical side effect.
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