These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Early gene expression profiles during intraoperative myocardial ischemia-reperfusion in cardiac surgery.
    Author: Arab S, Konstantinov IE, Boscarino C, Cukerman E, Mori A, Li J, Liu PP, Redington AN, Coles JG.
    Journal: J Thorac Cardiovasc Surg; 2007 Jul; 134(1):74-81, 81.e1-2. PubMed ID: 17599489.
    Abstract:
    OBJECTIVE: The effects of cold cardioplegic arrest and reperfusion on human ventricular gene expression are unknown. We tested the hypothesis that intraoperative ischemia-reperfusion under conditions of blood cardioplegic arrest would induce a unique myocardial genomic profile indicative of a cardioprotective response. METHODS: Right ventricular samples were serially acquired during surgical repair of ventricular septal defect. RESULTS: Expression profiling revealed 3 patterns of gene expression: (1) increased expression above control levels within 1 hour of cardioplegic arrest, with further amplification during early reperfusion; (2) increased expression limited to the reperfusion phase; and (3) reduced expression during reperfusion. Functional annotation and network mapping of differentially expressed genes indicated activation of multiple signaling pathways regulated by phosphatidylinositide 3'-OH kinase convergent on cellular growth and reparative programs. Also observed was increased expression of genes regulating hemoglobin synthesis, suggesting a novel cardioprotective pathway evoked during ischemia-reperfusion. CONCLUSION: Reversible myocardial ischemia-reperfusion during cardiac surgery is associated with an immediate genomic response that predicts a net cardioprotective phenotype.
    [Abstract] [Full Text] [Related] [New Search]